Users

Hydroxychloroquine Monitoring

Affected Drug

• P01BA02 Hydroxychloroquine

Baseline

Baseline: If >40yrs or pt has eye disease then needs baseline ophthalmologic exam including fundoscopy and visual fields. Ensure appropriate contraception for female patients during child bearing years. Avoid doses > 6.5 mg/kg as increased risk of retinopathy.

Follow-up

Follow-up: Annual ophthalmologic examination including fundoscopy and visual fields for all patients. Review contraception and ensure appropriate dosing. Monitor pt weight if close to 55 kg using usual doses, decrease usual dose with lower weights to decrease toxicity

Important Interactions

• Drugs:
  Interaction no sig drug interactions

Details

Conditions	System	Monitoring		ADE	Incidence	Recommendation
		Baseline	Follow-up
Notes -- All: baseline eye disease	Ocular	Ophthalmology exam incl fundoscopy + visual fields if age > 40 or baseline eye disease	Annual ophthalmology assessment	corneal & retinal deposition (dose and duration dependent)	3-4% with 10 years of use	Avoid doses greater than 6.5 mg/kg as increased risk of retinopathy; D/C if retinopathy occurs

References

• Repchinsky C, editor. Compendium of Pharmaceutical and Specialties, 2006 edition. Ottawa: The Canadian Pharmacists Association; 2006. ; Wallace DJ. Antimalarial drugs in the treatment of rheumatic disease. In: UpToDate, Basow, DS (Ed) UpToDate, Waltham, MA, 2010.
• Wallace DJ. Antimalarial drugs in the treatment of rheumatic disease. In: UpToDate, Basow, DS (Ed) UpToDate, Waltham, MA, 2010.