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Mycobacterium Avium Complex (MAC)- Prophylaxis

Posted Monday 24 September 2007 - 10:58 AM by David Chan

First Line Drugs

  1. CLARITHROMYCIN (J01FA09)

Second Line Drugs

  1. ZINC PREPARATIONS (C05AX04)

Reference

Comments/Instructions

Clarithromycin 500 mg, bid $41.41/week

Second-line therapies:

rifabutin 300 mg, once daily $52.50/week

-Prophylaxis is recommended for patients with a CD4 count below 0.1 ¥ 109 cells/L.

-Clarithromycin has been shown to prolong survival, whereas rifabutin does not confer a statistically significant survival advantage compared with placebo.

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