- Influenza treatment

Influenza treatment

Posted Wednesday 21 October 2009 - 05:15 AM by David Page

First Line Drugs

OSELTAMIVIR (J05AH02)

Reference

UpToDate

Comments/Instructions

Influenza treatment: Oral: Initiate treatment within 2 days of onset of symptoms; duration of treatment: 5 days:
Children <1 year (interim recommendations for treatment of swine influenza [CDC, 2009]):
<3 months: 12 mg twice daily
3-5 months: 20 mg twice daily
6-11 months: 25 mg twice daily
Children: 1-12 years:
≤15 kg: 30 mg twice daily
>15 kg - ≤23 kg: 45 mg twice daily
>23 kg - ≤40 kg: 60 mg twice daily
>40 kg: 75 mg twice daily
Adolescents ≥13 years: Refer to adult dosing.

DOSING: ELDERLY — Refer to adult dosing.

DOSING: RENAL IMPAIRMENT — Adults:

Clcr 10-30 mL/minute:
Treatment: Reduce dose to 75 mg once daily for 5 days.
Prophylaxis: Administer 75 mg every other day or 30 mg once daily.

CAPD (unlabeled dose): 30 mg once weekly (Robson, 2006)

Hemodialysis (unlabeled dose): 30 mg after every other session (Robson, 2006)

DOSING: HEPATIC IMPAIRMENT — No adjustment required in mild-to-moderate hepatic impairment. Safety and kinetics in patients with severe hepatic impairment have not been evaluated.

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