- Peripartum cardiomyopathy (PPCM)

Peripartum cardiomyopathy (PPCM)

Posted Friday 02 July 2010 - 18:56 PM by David Chan

First Line Drugs

BROMOCRIPTINE (G02CB01)

Reference

Sliwa K et al. Evaluation of Bromocriptine in the Treatment of Acute Severe Peripartum Cardiomyopathy A Proof-of-Concept Pilot Study. Circulation 2010;121:1465-1473

Comments/Instructions

Adding bromocriptine to standard HF therapy in women with PPCM improves NYHA class, LV systolic and diastolic function and degree of functional mitral regurgitation. Drug was well tolerated, with no thrombotic complications. While the drug stops lactation, growth and survival of infants was normal

Standard therapy (including diuretic, ACE inhibitor) (10 patients), plus warfarin if LVEF < 25% or LV thrombus, or this therapy plus bromocriptine plus cardiac MRI 4 to 6 weeks after diagnosis.

MyDrugRef