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bipolar (acute depression)

Posted Wednesday 11 August 2010 - 19:20 PM by Cam Ross

First Line Drugs

  1. CARBAMAZEPINE (N03AF01)

  2. VALPROIC ACID (N03AG01)

  3. OLANZAPINE (N05AH03)

  4. QUETIAPINE (N05AH04)

  5. LAMOTRIGINE (N03AX09)

Reference

Van Lieshout RJ, MacQueen GM. Efficacy and acceptability of mood stabilisers in the treatment of acute bipolar depression: systematic review. Br J Psychiatry 2010;196:266-273.

Comments/Instructions

Mood stabilizers have an effect in some people with acute bipolar depression, decreasing depression symptoms by at least 50% in at least 1 additional patient of every 10 patients who are given treatment instead of placebo. The mood stabilizers in the studies were the anticonvulsants carbamazepine (Tegretol), valproic acid (Depakote), and lamotrigine (Lamictal), and the atypical antipsychotics olanzapine (Zyprexa) and quetiapine (Serroquel). (LOE = 1a)

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